Ipamorelin: A Selective GH Secretagogue

A small, selective peptide

Ipamorelin is a pentapeptide (five amino acids) and one of the most selective growth-hormone secretagogues in the research class. It acts as an agonist at the ghrelin / growth-hormone secretagogue receptor (GHS-R1a), prompting the pituitary to release growth hormone in pulses that resemble the body's natural rhythm.

Why "selective" matters

Earlier secretagogues studied in research (such as GHRP-6) also stimulated GH, but tended to raise other hormones, cortisol and prolactin, and to drive strong hunger signaling. In published models, ipamorelin is noted for releasing GH with minimal effect on cortisol and prolactin, which is why it's described as a cleaner or more selective research tool.

Commonly paired in research

Ipamorelin is frequently studied alongside a GHRH analog such as CJC-1295. The two act on different receptors, the GHS-R and the GHRH receptor, so research often examines them together to look at the growth-hormone axis from both angles.

Research status

Ipamorelin is a research compound, not an approved therapeutic, supplied lyophilized for laboratory work. For laboratory research use only. Not for human consumption.